What is the difference between GHRP-2 and GHRP-6?

GHRP-2 produces stronger GH pulses with moderate cortisol and prolactin elevation. GHRP-6 is the original synthetic GHRP (from enkephalin structure) and strongly stimulates appetite via ghrelin/arcuate nucleus pathways in addition to GH release. Both are GHSR-1a agonists available from QSC Peptides in 5mg and 10mg vials.

Which is more potent — GHRP-2 or GHRP-6?

GHRP-2 has higher GH release potency per molar dose. GHRP-6 has greater appetite stimulation. For pure GH secretagogue potency, GHRP-2 is preferred; for ghrelin axis / appetite research, GHRP-6 is the compound of choice. Both are available from QSC Peptides.

// Compound Comparison — QSC Peptides

GHRP-2 vs GHRP-6Full Pharmacology Comparison — QSC Peptides Research Compounds

GHRP-2 and GHRP-6 are both synthetic hexapeptide GHSR-1a agonists — but they differ in GH potency, appetite stimulation, cortisol elevation, and research applications. Here is the complete breakdown from QSC Peptides.

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// Side-by-Side

GHRP-2 vs GHRP-6 Comparison Table

Property	GHRP-2 (Pralmorelin)	GHRP-6	Ipamorelin (reference)
Drug Class	GH Secretagogue	GH Secretagogue	GH Secretagogue
Receptor Target	GHSR-1a	GHSR-1a	GHSR-1a
Sequence	D-Ala-D-2Nal-Ala-Trp-D-Phe-Lys-NH₂	His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂	Aib-His-D-2Nal-D-Phe-Lys-NH₂
Molecular Weight	817.9 Da	873.0 Da	711.9 Da
GH Release Potency	High	Moderate-High	Moderate
Cortisol Elevation	Moderate	Low-Moderate	None
Prolactin Elevation	Moderate	Low	None
Appetite Stimulation	Minimal	Strong	None
Half-Life	~15–25 min	~15–25 min	~2 hours
Historical origin	Synthetic design	Met-enkephalin derived	Synthetic design
QSC Peptides Price (10-vial 5mg)	$180	$180	$190