// GH Releasing Peptide-2 · Pralmorelin · GHSR-1a Agonist · Hexapeptide

GHRP-2Growth Hormone Releasing Peptide-2 (Pralmorelin) — Research Reference by QSC Peptides

GHRP-2 (Pralmorelin, KP-102) is a potent synthetic hexapeptide GHSR-1a agonist producing among the strongest GH pulses of any synthetic secretagogue. Also elevates cortisol and prolactin moderately — distinct from the clean profile of Ipamorelin. QSC Peptides offers 5mg and 10mg vials.

Molecular Profile

SequenceD-Ala-D-2Nal-Ala-Trp-D-Phe-Lys-NH₂
MW817.9 Da
TypeHexapeptide
TargetGHSR-1a (Ghrelin-R)
GH PotencyHigh
CortisolModerate elevation
ProlactinModerate elevation
QSC Purity≥99%
Sizes5mg & 10mg vials
QSC Peptides ≥99% Purity Verified COA Every Order Free USA USPS/FedEx USA Domestic Stock
// Mechanism of Action

How GHRP-2 Works

GHRP-2 (D-Ala-D-2Nal-Ala-Trp-D-Phe-Lys-NH₂, Pralmorelin, KP-102) is a synthetic hexapeptide acting as a potent agonist at GHSR-1a (ghrelin receptor) on pituitary somatotrophs and hypothalamic neurons. Receptor activation drives Gq → PLC → IP3 → intracellular Ca²⁺ → GH granule exocytosis, and additionally suppresses somatostatin tone.

GHRP-2 produces among the strongest GH pulses of any synthetic secretagogue, but unlike Ipamorelin, it also activates secondary pathways that elevate cortisol (moderate) and prolactin (moderate) by engaging corticotroph and lactotroph receptors at higher concentrations. This broader receptor pharmacology is scientifically useful for studying the full spectrum of GHSR-1a effector biology, including HPA axis interactions.

GHRP-2 vs Ipamorelin

GHRP-2 has higher GH release potency but less receptor selectivity. Ipamorelin is preferred for isolated GH research; GHRP-2 is preferred when studying broader ghrelin receptor pharmacology including stress axis interactions. Both are available from QSC Peptides.

// Research Applications

Research Applications

  • GHSR-1a agonist pharmacology: GH dose-response characterization and receptor activation kinetics
  • HPA axis interaction: Studying GHSR-1a-mediated cortisol elevation and adrenal cortex signaling
  • GH/IGF-1 axis: Quantifying downstream IGF-1 and IGFBP-3 responses to potent GHSR-1a stimulation
  • Somatostatin suppression: GHRP-2-mediated reduction in hypothalamic somatostatin inhibition
  • Selectivity comparison: Benchmarking vs Ipamorelin, GHRP-6, and Hexarelin for selectivity profiling
  • Cardiac research: GHSR-1a expression and function in cardiac tissue
// QSC Peptides Products

Buy from QSC Peptides

Research-grade · ≥99% purity · COA · Free USA USPS/FedEx · US domestic warehouse

GH Secretagogue
GHRP-2 5mg | 10-Vial Kit
50mg Total

QSC Peptides · Potent GHSR-1a

≥99% Pure · COA
GH Secretagogue
GHRP-2 5mg | 20-Vial Kit
100mg Total

QSC Peptides

≥99% Pure · COA
GH Secretagogue
GHRP-2 10mg | 10-Vial Kit
100mg Total

QSC Peptides

≥99% Pure · COA
GH Secretagogue
GHRP-2 10mg | 20-Vial Kit
200mg Total

QSC Peptides

≥99% Pure · COA
// FAQ

Frequently Asked Questions

GHRP-2 (Pralmorelin / KP-102) is a hexapeptide GHSR-1a agonist. Sequence: D-Ala-D-2Nal-Ala-Trp-D-Phe-Lys-NH₂. MW 817.9 Da. Potent GH secretagogue with moderate cortisol and prolactin elevation. QSC Peptides offers 5mg and 10mg vials.
GHRP-2 has higher GH release potency but elevates cortisol and prolactin moderately. Ipamorelin produces clean GH pulses with no cortisol/prolactin effect. For isolated GH research, Ipamorelin is preferred; for full GHSR-1a pharmacology, GHRP-2 is used.
Yes. Free USPS/FedEx domestic shipping on all orders.
// Related Compounds

GH Axis Research Stack

GHRP-6
GH Secretagogue
View reference →
Ipamorelin
Selective GHSR-1a
View reference →
Hexarelin
Most Potent GHSR-1a
View reference →
CJC-1295
GHRH Analog
View reference →
HGH / Somatropin
Direct GH
View reference →
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