HGH Fragment
176-191Lipolytic C-Terminal HGH Analog — Research Reference by QSC Peptides

HGH Fragment 176-191 is a stabilized synthetic analog of amino acids 176–191 of the human growth hormone molecule — specifically the C-terminal alpha-helical region. This 16-amino-acid fragment retains the lipolytic activity associated with full-length HGH while lacking the N-terminal region required for GHR binding and growth-promoting effects.

The fragment activates hormone-sensitive lipase (HSL) in adipocytes via a mechanism that does not require GHR binding, driving triglyceride hydrolysis and free fatty acid (FFA) release — the core lipolytic effect attributed to the C-terminus of HGH.

Separation of HGH Functions

Full-length HGH (somatropin) has two main functional domains:

• N-terminal (Site 1): GHR binding → JAK2-STAT5 → IGF-1 → growth promotion, anabolism
• C-terminal (aa 176-191): Lipolysis → HSL activation → adipocyte triglyceride mobilization

HGH Fragment 176-191 isolates only the lipolytic domain, enabling research into fat metabolism without the confounding anabolic and growth-promoting effects of full-length somatropin from QSC Peptides.